Vitexin and isovitexin from the Leaves of Ficus deltoidea with in-vivo α-glucosidase inhibition
The leaves of Ficus deltoidea are used as a traditional medicine by diabetes patients in Malaysia.
Aim of the study
The objective of the study is to identify and evaluate bioactive constituents with in vivo α-glucosidase inhibition.
Materials and Methods
The partitioned extracts, subfractions and pure bioactive constituents were subjected to α-glucosidase inhibition assay. The identified bioactive constituents were administered orally to sucrose loaded normoglycemic mice and induced diabetic rats. The postprandial blood glucose levels were monitored at 30 min interval. Acute toxicity was evaluated in both normoglycemic mice and induced diabetic rats.